Естрогенна детермінація гепатотропної дії кріоекстракту плаценти на тлі хронічного етанол-тетрахлорметанового ураження печінки та трикомпонентної противиразкової терапії в експерименті

Abstract

The problem of antibiotic-associated liver lesions is still relevant, in particular against the background of three-component antiulcer therapy (esomeprazole, clarithromycin and metronidazole), or when it is necessary to use antibacterial drugs in patients with chronic liver lesions. The purpose of the study is to characterize the effect of different levels of estradiol saturation in the body of female rats on the hepatoprotective activity of placenta cryoextract against the background of chronic ethanol-tetrachloromethane liver damage and three-component antiulcer therapy. It was established that the administration of cryoextract of the placenta to female rats reduces the hyperactivation of lipid peroxidation in liver tissues caused by chronic ethanol-tetrachloromethane damage and the combined injection of the proton pump inhibitor esomeprazole, the macrolide antibiotic clarithromycin and the nitroimidazole antibiotic metronidazole both in animals without changes in hormonal status and in ovariectomized female rats and subsequent hormone replacement therapy. The lowest content of reactants with thiobarbituric acid in liver homogenates was found against the background of five injections of the studied cryoextract to sham-operated female rats, which were injected with estradiol hemihydrate, in which this indicator was 10.3±1.02 (95% CI: 8.3–12 ,3) μmol/kg tissue.