Therapeutic potential of conditioned media from mesenchymal stem cells in regulating NO production in kidney disease

Гладких, Ф.В.

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dc.contributor.author	Гладких, Ф.В.
dc.date.accessioned	2025-02-23T16:37:53Z
dc.date.available	2025-02-23T16:37:53Z
dc.date.issued	2025-02-23
dc.identifier.citation	Hladkykh FV. Therapeutic potential of conditioned media from mesenchymal stem cells in regulating NO production in kidney disease. Materials of the 4th International scientific-rractical conference "Science in motion: classic and modern tools and methods in scientific investigations"; February 21, 2025; Vinnytsia-Vienna (Austria): International Centre Corporative Management & European Scientific Platform; 2025, р. 1190–2. DOI: https://doi.org/10.5281/zenodo.14913939	uk_UA
dc.identifier.uri	https://doi.org/10.5281/zenodo.14913939
dc.identifier.uri	https://pubmed.com.ua/xmlui/handle/123456789/1123
dc.description	Nitric oxide (NO) is a vital signaling molecule that plays an essential role in numerous physiological processes, including the regulation of blood pressure, immune response, and neurotransmission. It is widely recognized for its vasodilatory properties, which help in the relaxation of blood vessels, and it acts in concert with other gaseous molecules like hydrogen sulfide (H2S) and carbon monoxide (CO). NO is synthesized from the amino acid L-arginine by a group of enzymes known as nitric oxide synthases (NOS). These enzymes catalyze the conversion of L-arginine into L-citrulline and NO, with three major isoforms identified: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). These isoforms are expressed in various tissues, including the kidneys, where they contribute to maintaining renal function by regulating blood flow, glomerular filtration, and interstitial pressure. NO production in the kidney is crucial for maintaining the balance of vasodilation and vasoconstriction, and it is produced by different kidney cell types, such as endothelial cells, mesangial cells, and podocytes. Podocyte injury is a hallmark of membranous nephropathy (MN), a condition characterized by the deposition of immune complexes beneath the glomerular visceral epithelial cells. The immune-mediated damage to podocytes leads to proteinuria and progressive kidney dysfunction. In recent years, there has been growing interest in the potential therapeutic use of cryopreserved biological agents (CfBA), such as conditioned media from mesenchymal stem cells (MSC-CM), as a potential treatment for autoimmune kidney diseases like MN. These agents are believed to have regenerative properties and may help modulate various biological pathways, including those involving NO.	uk_UA
dc.description.abstract	Hladkykh FV. Therapeutic potential of conditioned media from mesenchymal stem cells in regulating NO production in kidney disease. Materials of the 4th International scientific-rractical conference "Science in motion: classic and modern tools and methods in scientific investigations"; February 21, 2025; Vinnytsia-Vienna (Austria): International Centre Corporative Management & European Scientific Platform; 2025, р. 1190–2. DOI: https://doi.org/10.5281/zenodo.14913939	uk_UA
dc.language.iso	en_US	uk_UA
dc.publisher	Materials of the 4th International scientific-rractical conference "Science in motion: classic and modern tools and methods in scientific investigations"	uk_UA
dc.subject	NO	uk_UA
dc.subject	kidney disease	uk_UA
dc.subject	mesenchymal stem cells	uk_UA
dc.title	Therapeutic potential of conditioned media from mesenchymal stem cells in regulating NO production in kidney disease	uk_UA
dc.title.alternative	Therapeutic potential of conditioned media from mesenchymal stem cells in regulating NO production in kidney disease	uk_UA
dc.type	Thesis	uk_UA